The ketogenic diet is a promising adjuvant cancer therapy that can sensitize most cancers to standard treatment. Preclinical and clinical studies suggest that the ketogenic diet can enhance the antitumor effects of classic chemo- and radiotherapy and increase the quality of life of cancer patients. However, more molecular studies and uniformly controlled clinical trials are needed to fully understand the mechanisms of the ketogenic diet as a cancer therapy and its application in clinical practice.
Metabolism of Exogenous D-Beta-Hydroxybutyrate, an Energy Substrate Avidly Consumed by the Heart and Kidney
The article discusses the potential benefits of D-BHB supplements as an alternative to a high-fat ketogenic diet for achieving ketosis. The study found that D-BHB is rapidly absorbed, significantly more ketogenic and provides fewer calories than other supplements. The research suggests that D-BHB supplements have potential therapeutic applications in cardiac and chronic kidney diseases.
Gastrointestinal Effects of Exogenous Ketone Drinks are Infrequent, Mild, and Vary According to Ketone Compound and Dose
The study examines the gastrointestinal tolerability of exogenous ketone drinks during three studies. Participants reported mild and acute symptoms following KME and KS drinks, which were fully resolved by the end of the study. The study concludes that exogenous ketone drinks cause mild gastrointestinal symptoms that depend on the compound consumed, amount, time, and exercise.
Ketone ester supplementation blunts overreaching symptoms during endurance training overload
The article discusses the hypothesis that oral ketones can prevent overreaching caused by endurance training. Elevated blood ketones are known to attenuate net muscle protein breakdown and catabolic events during an energy deficit. Therefore, the study hypothesized that oral ketones could also mitigate the negative effects of endurance training-induced overreaching.
Context is key: exogenous ketosis and athletic performance
Ketone bodies are synthesized from lipids during prolonged caloric deprivation and have pleiotropic effects on metabolism. They improve energetics and fuel sparing, and may be used to enhance human exercise endurance performance by mimicking advantageous aspects of starvation physiology. While exercising during endogenous ketosis may not be advantageous, the delivery of exogenous ketones creates a novel physiological state with high circulating ketone concentrations and replete carbohydrate stores, offering potential benefits for endurance performance.
1 of 9Next