The ketogenic diet is a promising adjuvant cancer therapy that can sensitize most cancers to standard treatment. Preclinical and clinical studies suggest that the ketogenic diet can enhance the antitumor effects of classic chemo- and radiotherapy and increase the quality of life of cancer patients. However, more molecular studies and uniformly controlled clinical trials are needed to fully understand the mechanisms of the ketogenic diet as a cancer therapy and its application in clinical practice.
Ketone ester supplementation blunts overreaching symptoms during endurance training overload
The article discusses the hypothesis that oral ketones can prevent overreaching caused by endurance training. Elevated blood ketones are known to attenuate net muscle protein breakdown and catabolic events during an energy deficit. Therefore, the study hypothesized that oral ketones could also mitigate the negative effects of endurance training-induced overreaching.
Context is key: exogenous ketosis and athletic performance
Ketone bodies are synthesized from lipids during prolonged caloric deprivation and have pleiotropic effects on metabolism. They improve energetics and fuel sparing, and may be used to enhance human exercise endurance performance by mimicking advantageous aspects of starvation physiology. While exercising during endogenous ketosis may not be advantageous, the delivery of exogenous ketones creates a novel physiological state with high circulating ketone concentrations and replete carbohydrate stores, offering potential benefits for endurance performance.
The glucose-lowering effects of exogenous ketones: is there therapeutic potential?
In this article, exogenous ketone supplements have been shown to be effective in stimulating ketosis, which can be used to provide energy to the brain during periods of low glucose availability, as well as in other tissues. Researchers have investigated the effects of acute ingestion of the ketone monoester on the postprandial glycaemic response in young, healthy individuals. They found that the ketone monoester resulted in a significant reduction in plasma glucose area under the curve by 16% over the 2-hour period, without further elevating insulin compared to glucose alone. This result may have potential implications for individuals with type 2 diabetes mellitus.
Metabolic characteristics of keto-adapted ultra-endurance runners
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