Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease
Brain glucose uptake is impaired in Alzheimer's disease (AD), and increasing ketone availability to the brain via moderate nutritional ketosis has a modest beneficial effect on cognitive outcomes in mild-to-moderate AD and in mild cognitive impairment. This can be achieved through a high-fat ketogenic diet, supplements providing medium-chain triglycerides, or ketone esters. The development of therapeutic strategies for AD should consider how the underlying problem of deteriorating brain fuel supply can be corrected or delayed.