The ketogenic diet is a promising adjuvant cancer therapy that can sensitize most cancers to standard treatment. Preclinical and clinical studies suggest that the ketogenic diet can enhance the antitumor effects of classic chemo- and radiotherapy and increase the quality of life of cancer patients. However, more molecular studies and uniformly controlled clinical trials are needed to fully understand the mechanisms of the ketogenic diet as a cancer therapy and its application in clinical practice.
Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease
Brain glucose uptake is impaired in Alzheimer's disease (AD), and increasing ketone availability to the brain via moderate nutritional ketosis has a modest beneficial effect on cognitive outcomes in mild-to-moderate AD and in mild cognitive impairment. This can be achieved through a high-fat ketogenic diet, supplements providing medium-chain triglycerides, or ketone esters. The development of therapeutic strategies for AD should consider how the underlying problem of deteriorating brain fuel supply can be corrected or delayed.
Comparison of Ketogenic Diets with and without Ketone Salts versus a Low-Fat Diet: Liver Fat Responses in Overweight Adults
This study compared the effect of a hypocaloric ketogenic diet (KD) with or without ketone supplementation (KS) and a low-fat diet (LFD) on liver fat reduction in overweight adults. The results showed that all diets significantly reduced liver fat, including in participants with nonalcoholic fatty liver disease (NAFLD), with no significant differences between the groups. The study suggests that both KDs and LFDs can be used to reduce liver fat in individuals with NAFLD.
Exogenous Ketones as Therapeutic Signaling Molecules in High-Stress Occupations: Implications for Mitigating Oxidative Stress and Mitochondrial Dysfunction in Future Research
High-stress occupations are associated with cardiometabolic diseases due to chronic stressors. Ketones, specifically R-βHB, modulate intracellular signaling cascades to promote a robust mitochondrial environment that favors reductions in oxidative stress and inflammation. The scope of this review is to detail the mechanisms of R-βHB as a signaling metabolite and the role that exogenous ketones might play in mitigating diseases in individuals serving in high-stress occupations.
Metabolism of Exogenous D-Beta-Hydroxybutyrate, an Energy Substrate Avidly Consumed by the Heart and Kidney
The article discusses the potential benefits of D-BHB supplements as an alternative to a high-fat ketogenic diet for achieving ketosis. The study found that D-BHB is rapidly absorbed, significantly more ketogenic and provides fewer calories than other supplements. The research suggests that D-BHB supplements have potential therapeutic applications in cardiac and chronic kidney diseases.
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